Studying the Effect of Cyperus rotundus Hydroalcoholic Extract on Memory Retrieval Disorder Caused by Acute Stress in Mice

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There are several reports that stress causes memory impairment. On the other hand, research has shown that Cyperus Rotundus (C. rotundus) extract improves memory and enhances information retrieval. In the current study, the possible ameliorating impacts of C. rotundus hydroalcoholic extract on stress-induced memory retrieval impairment were investigated. In this study, adult male laboratory mice were divided into two groups: stressed and non-stressed, and each of these groups was further divided into two subgroups: control groups receiving saline and those treated with C. rotundus extract. First, the mice received the substances by gavage for 21 or 7 days. One day after the last gavage, the animals were trained using a passive avoidance memory test device, and 24 hours after teaching, they were subjected to acute stress and immediately underwent a memory test. The latency to enter the dark room and the time spent in the darkroom of the device were recorded as a measure of passive avoidance memory retrieval. According to the findings obtained, pre-test stress significantly decreased the latency to enter the dark room and increased the time spent in the dark room. Pre-training gavage of the extract reversed the latency to enter and also significantly decreased the time spent in the dark room. It seems that the hydroalcoholic extract of C. rotundus improves the ability to retrieve information from long-term memory and reduces the destructive impact of acute stress on memory retrieval, depending on the time of consumption.