Studying the Anti-Anxiety and Anti-Convulsant Impacts of Royal Jelly in Mice

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One of the secretory products of bees is called royal jelly, which has already been stated to have useful impacts on the nervous system. The purpose of this study was to study the effect of royal jelly in decreasing anxiety and seizures in mice. To survey the anticonvulsant impact of royal jelly, 25 male mice were randomly divided into 5 groups. After half an hour, strychnine was injected into the animals to induce convulsions. Mortality percentage, seizure duration, and seizure onset time were recorded. To investigate the effect on anxiety, 35 male mice were divided into 5 groups. Data analysis was done by one-way analysis of variance and P<0.05 was considered statistically significant. Based on the results, the doses of 200 and 400 mg/kg of royal jelly delayed the onset and decreased the duration of seizures compared to the group of control. The percentage of mortality in different doses of royal jelly showed a significant reduction compared to the control group (P<0.05). In the anxiety model, doses of 50 and 100 mg/kg of royal jelly, stopping time, and times of entering the arms compared to the control group demonstrated a significant increase (P<0.05). According to the findings obtained from the present study, it can be concluded that the performance of royal jelly can effectively decrease strychnine-induced convulsions and modulate anxiety behaviors in mice.