The treatment of infectious and autoimmune diseases has experienced many changes in the past few years. Currently, cancer treatment is usually based on pathological and clinical methods. The most common cancer treatment is limited to chemotherapy, radiation therapy, and surgery, however, the treatment is still not optimal. Common problems in some diseases treatment, especially cancer, include non-specific and systematic distribution of medicinal agents, insufficient drug concentration at the operation site, intolerable toxicity, and drug resistance. The application and development of nanotechnology for cancer treatment have attracted a lot of attention in recent years. This technology provides a unique approach to cancer through early detection and cancer treatment. The design and development of new drug delivery systems not only increase the activity of the drug in the target tissue but also reduce the toxicity of the drug to a great extent and release it at the site of operation in a controlled manner. Niosomal vesicles contain non-ionic surfactants, which are non-toxic, biodegradable, stable, and cheap and can be utilized for targeted drug delivery. High purity, greater chemical stability, proper drug storage, various types of availability of non-ionic surfactants, and cheapness are the most important advantages of niosomes.