Investigating the Effect of Malathion on Cytotoxicity and Carcinogenesis in Mice

Download PDF

The use of different agricultural poisons causes different effects on body tissues. In the present study, the impact of Malathion on sex hormones and its carcinogenic impact on skin contact were studied in mice. In this study, 30 adult male mice were divided into treatment and control groups. In the treatment group, Malathion with a concentration of 1 ppm was poured on the skin in the amount of 1 ml for 12 weeks. Eventually, serum levels of testosterone, luteinizing, and follicular stimulating hormones were measured, and tissue samples were taken from the desired organs after necropsy. Cytotoxicity was also measured by micronucleus test and MTT in vitro and IC50 percentage was determined. According to the results, there was no significant change in the luteinizing hormone treatment groups compared to the control group, but follicle-stimulating hormone and testosterone showed a significant decrease. Mild hepatotoxicity was observed in the histological examination in the treatment groups. The frequency of micronuclei in different concentrations of Malathion was significantly different from the control group (p < 0.05). From the findings of this study, it can be concluded that skin contact with Malathion can have destructive impacts on sex hormones as well as body tissues.