A Comprehensive Review of Controlled Drug Release Delivery Systems: Current Status and Future Directions

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Controlled-release systems regulate drug plasma concentration after administration through pre determined patterns over a fixed period. The release rate should determine drug absorption and concentration. These formulations reduce daily dosing frequency. This article discusses ideal requirements, advantages, properties, and approaches for developing controlled-release formulations to improve drug delivery. This involves delivering drugs at a pre-set rate for a limited period, either locally or systemically. This method, utilizing drug-encapsulating devices, offers advantages over traditional methods, including tailored release rates, drug protection, and increased patient comfort. Controlled-release drug delivery systems maintain a uniform plasma concentration within the therapeutic range, minimizing side effects and administration frequency. Oral sustained release (SR) products optimize drug properties, reducing dosing frequency and ensuring maximum drug utility, reduced side effects, and quicker cure or control conditions. Technological advancements have revolutionized medication methods with controlled drug delivery systems, offering benefits like multiple dosing and single dosing. Oral CRDD provides continuous oral delivery of drugs at predictable kinetics for a predetermined period, targeting specific regions within the gastrointestinal tract for local or systemic action. This technique reduces drug administration frequency and maintains constant drug levels in the patient’s bloodstream, increasing its therapeutic effectiveness.