This comprehensive review examines the potential of aloe vera powder as a potent bioenhancer. Aloe vera has long been recognized for its numerous health benefits, and recent research has focused on its bioenhancing properties. The review provides a detailed analysis of the composition and bioactive components of aloe vera powder, highlighting its vitamins, minerals, polysaccharides, and other compounds. It explores the mechanisms through which aloe vera powder enhances bioavailability, including improved absorption, increased cellular uptake, and modulation of drug metabolism enzymes. The review discusses the diverse applications of aloe vera powder as a bioenhancer in pharmaceuticals, nutraceuticals, and cosmeceuticals. Safety considerations and potential adverse effects are also addressed, emphasizing the importance of quality control in manufacturing processes. The review concludes by identifying research gaps and future directions for investigating the bioenhancing potential of aloe vera powder. Overall, this comprehensive review consolidates existing knowledge and highlights the potential of aloe vera powder as a versatile bioenhancer, contributing to advancements in drug delivery and optimization of bioactive compounds.