International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2020   Volume 10   Issue 4

In-silico Molecular Docking, ADME and Drug Likeness Predictions of Some α-alkylidene-β-ethoxycarbonyl Cyclopentanones
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Feten Beji, Reem al Harbi, Arshi Naqvi
Citation
Beji F, Harbi R A, Naqvi A. In-silico Molecular Docking, ADME and Drug Likeness Predictions of Some α-alkylidene-β-ethoxycarbonyl Cyclopentanones . Int j pharm phytopharm res 2020;10(4):126-32
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Abstract

Computer-aided drug design (CADD) conception in the present-day scenario has transfigured the total drug discovery and development program. The pharmacodynamic and pharmacokinetic aspects of a drug candidate play a key role in deciding its fate as a therapeutic agent. The pharmacokinetic fortune of any drug candidate is determined by various properties like its absorption, distribution, metabolism, and elimination (ADME). In this report, an in-silico examination of α-alkylidene-β-ethoxycarbonyl cyclopentanones (1-7) was persuaded based on various physico-chemical parameters to predict their drug-likeness, pharmacokinetic and docking profile utilizing different computational tools. 


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