International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2020   Volume 10   Issue 4

Bacteriological Analysis with Antimicrobial Sensitivity and Resistance Pattern in Blood Culture of Septicemic Patient from Different Wards of a Tertiary Care Hospital in India ‎
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Rohit Tiwari, Suraj Sandil, Parminder Nain, Jaspreet Kaur
Citation
Tiwari R, Sandil S, Nain P, Kaur J. Bacteriological Analysis with Antimicrobial Sensitivity and Resistance Pattern in Blood Culture of Septicemic Patient from Different Wards of a Tertiary Care Hospital in India ‎. Int j pharm phytopharm res 2020;10(4):112-9
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Abstract

Background: Septicemia is one of the leading causes of morbidity and mortality in India where a large number of broad-spectrum antibiotics as empirical therapy implement against causative microorganism has led to the emergence of multidrug-resistant of these strains. Object: The present study was conducted to determine bacterial etiology with antibiotic susceptibility and resistance profile of isolated organisms from septicemia. Methods: This retrospective observational study was conducted over a period of six months to evaluate the blood culture, sensitivity, and resistance pattern of various antimicrobial agents used in septicemic patients. Results: We collected and analyzed a total of 380 blood culture reports during the study period of which 345 (90.78%) samples were found to be positive, out of which 62.02 % was found to be gram-positive bacteria whereas 37.98% was gram-negative bacteria. The most commonly isolated organisms were Staphylococcus aureus (83.28%), Micrococcus species (6%), Enterococcus species (6%), and Staphylococcus saprophyticus (5%) under gram-positive bacteria. The majority of organisms isolated were resistant to commonly used antibiotics like 2nd & 3rd generation cephalosporin, which showed more than 90% resistance for gram-positive and gram-negative organisms. Conclusion: The results obtained from this study showed aminoglycosides as a highly sensitive antibiotic and cephalosporin as a highly resistant antibiotic. This study would guide the clinicians to formulate appropriate treatment strategies as well as to take various preventive measures which ultimately would help to decrease sepsis-related mortality. 


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