The Co-Crystal Approach: An Avenue for Improving Drug Bioavailability

Samarpan Sarangi; Simran Singh; Jigyasha Dhakal; Bunu Khatiwada; Arnab Das; Prithviraj Chakraborty

doi:10.51847/yf34beVi2Y

2023 Volume 13 Issue 1

The Co-Crystal Approach: An Avenue for Improving Drug Bioavailability
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Samarpan Sarangi , Simran Singh , Jigyasha Dhakal , Bunu Khatiwada , Arnab Das , Prithviraj Chakraborty^*✉

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Vancouver

Sarangi S, Singh S, Dhakal J, Khatiwada B, Das A, Chakraborty P. The Co-Crystal Approach: An Avenue for Improving Drug Bioavailability. Int J Pharm Phytopharmacol Res. 2023;13(1):19-32. https://doi.org/10.51847/yf34beVi2Y

APA

Sarangi, S., Singh, S., Dhakal, J., Khatiwada, B., Das, A., & Chakraborty, P. (2023). The Co-Crystal Approach: An Avenue for Improving Drug Bioavailability. International Journal of Pharmaceutical And Phytopharmacological Research, 13(1), 19-32. https://doi.org/10.51847/yf34beVi2Y

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Abstract

The main concern of formulators while designing and developing a new pharmaceutical formulation is the poor water solubility and permeability in the present scenario. These problems are most common in group III and IV medications, and they affect the bioavailability of dose forms. There are many methods for dealing with these problems, but all of them have serious flaws, such as the fact that they all depend on the physical and chemical makeup of the medication. To deal with such issues, cocrystal is a simple and effective way to increase the solubility and permeability of a medicinal component without changing the pharmacological effects of the drug. The solubility, dissolution profile, pharmacokinetics, and stability of a drug can be improved by cocrystallization with a conformer. This review article provides an overview of cocrystals such as properties, preparation method, evaluation, advantages, and uses. This review will also surely give a brief introduction to cocrystals.