International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2021   Volume 11   Issue 5

Novel Synthesis of Keto acid Precursor Derivative for Oxidation of Lambda-Carrageenan Polysaccharide by Alkaline Permanganate
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Hassan RM. Novel Synthesis of Keto acid Precursor Derivative for Oxidation of Lambda-Carrageenan Polysaccharide by Alkaline Permanganate. Int J Pharm Phytopharmacol Res. 2021;11(5):41-8. https://doi.org/10.51847/w1rEd61Svj
APA
Hassan, R. M. (2021). Novel Synthesis of Keto acid Precursor Derivative for Oxidation of Lambda-Carrageenan Polysaccharide by Alkaline Permanganate. International Journal of Pharmaceutical And Phytopharmacological Research, 11(5), 41-48. https://doi.org/10.51847/w1rEd61Svj
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Abstract

Novel Keto-acid derivatives of lambda-carrageenan (LCAR) as sulfated polysaccharides were synthesized through LCAR oxidation by permanganate ion in alkaline media at pH`s > 12. Stoichiometric molar ratios of LCAR, MnO4- and NaF were mixed in alkaline solutions of pH >12. The mixture was stirred until reaction completion (~48 hr), then the formed colloidal precipitate of MnF4 was isolated by filtrations. A rotary evaporator was used to concentrate the filtrate to about one-fifth of its original volume, and then acidified by acetic acid to pHs of ca. 5-6. Vacuum evaporation was applied to that remains filtrate until drying, and then it was kept in a desiccator for use. The hydroxyl amine and 2,4-dinitrophenyl hydrazine were used to identify the oxidation product. The formation of the corresponding 2,4-dinitrophenyl hydrazone and dioxime derivatives, respectively, indicated the formation of ketoacid-LCAR as the final oxidation product. Such oxidation products can be applied as alternative promising in pharmaceutical, medicine, biomedicine and food industry technologies.

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