%0 Journal Article
%T Novel Synthesis of Keto acid Precursor Derivative for Oxidation of Lambda-Carrageenan Polysaccharide by Alkaline Permanganate
%A Refat M. Hassan
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2021
%V 11
%N 5
%R 10.51847/w1rEd61Svj
%P 41-48
%X Novel Keto-acid derivatives of lambda-carrageenan (LCAR) as sulfated polysaccharides were synthesized through LCAR oxidation by permanganate ion in alkaline media at pH`s > 12. Stoichiometric molar ratios of LCAR, MnO4- and NaF were mixed in alkaline solutions of pH >12. The mixture was stirred until reaction completion (~48 hr), then the formed colloidal precipitate of MnF4 was isolated by filtrations. A rotary evaporator was used to concentrate the filtrate to about one-fifth of its original volume, and then acidified by acetic acid to pHs of ca. 5-6. Vacuum evaporation was applied to that remains filtrate until drying, and then it was kept in a desiccator for use. The hydroxyl amine and 2,4-dinitrophenyl hydrazine were used to identify the oxidation product. The formation of the corresponding 2,4-dinitrophenyl hydrazone and dioxime derivatives, respectively, indicated the formation of ketoacid-LCAR as the final oxidation product. Such oxidation products can be applied as alternative promising in pharmaceutical, medicine, biomedicine and food industry technologies. 
%U https://eijppr.com/article/novel-synthesis-of-keto-acid-precursor-derivative-for-oxidation-of-lambda-carrageenan-polysaccharide-q0ahjthmd5fwaz8