TY  - JOUR
T1  - Novel Synthesis of Keto acid Precursor Derivative for Oxidation of Lambda-Carrageenan Polysaccharide by Alkaline Permanganate
A1  - Refat M. Hassan
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2021
VL  - 11
IS  - 5
DO  - 10.51847/w1rEd61Svj
SP  - 41
EP  - 48
N2  - Novel Keto-acid derivatives of lambda-carrageenan (LCAR) as sulfated polysaccharides were synthesized through LCAR oxidation by permanganate ion in alkaline media at pH`s > 12. Stoichiometric molar ratios of LCAR, MnO4- and NaF were mixed in alkaline solutions of pH >12. The mixture was stirred until reaction completion (~48 hr), then the formed colloidal precipitate of MnF4 was isolated by filtrations. A rotary evaporator was used to concentrate the filtrate to about one-fifth of its original volume, and then acidified by acetic acid to pHs of ca. 5-6. Vacuum evaporation was applied to that remains filtrate until drying, and then it was kept in a desiccator for use. The hydroxyl amine and 2,4-dinitrophenyl hydrazine were used to identify the oxidation product. The formation of the corresponding 2,4-dinitrophenyl hydrazone and dioxime derivatives, respectively, indicated the formation of ketoacid-LCAR as the final oxidation product. Such oxidation products can be applied as alternative promising in pharmaceutical, medicine, biomedicine and food industry technologies. 
UR  - https://eijppr.com/article/novel-synthesis-of-keto-acid-precursor-derivative-for-oxidation-of-lambda-carrageenan-polysaccharide-q0ahjthmd5fwaz8
ER  -