International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2021   Volume 11   Issue 1

Effectiveness of Non-benzodiazepine Antiepileptic Drugs in Benzodiazepine-resistant ‎Convulsive Status Epilepticus
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Anfal Atallah S Alamrani, Ali Mohamed S Alsada, Taif Naif R Alruwaili, Jumanah Faisal I Algoufi, Ammar Khalid S Alghanmi, Abdulmajeed Hisham A Alwabel, Abdulaziz Nasser A Alahmari, Abdullah Ayed A Alshahrani, Rahmah Mohammad M Alhawiti
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Vancouver
Alamrani A A S, Alsada A M S, Alruwaili T N R, Algoufi J F I, Alghanmi A K S, Alwabel A H A, et al. Effectiveness of Non-benzodiazepine Antiepileptic Drugs in Benzodiazepine-resistant ‎Convulsive Status Epilepticus. Int j pharm phytopharm res. 2021;11(1):149-154. https://doi.org/10.51847/nyFViZbJja
APA
Alamrani, A. A. S., Alsada, A. M. S., Alruwaili, T. N. R., Algoufi, J. F. I., Alghanmi, A. K. S., Alwabel, A. H. A., & et al (2021). Effectiveness of Non-benzodiazepine Antiepileptic Drugs in Benzodiazepine-resistant ‎Convulsive Status Epilepticus. International Journal Of Pharmaceutical And Phytopharmacological Research, 11(1),149-154. https://doi.org/10.51847/nyFViZbJja
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Abstract

Background: Time-dependent pharmacoresistance is a major therapeutic problem in SE and CSE. As seizures continue, pharmacoresistance develops progressively. The anti-seizure effectiveness of benzodiazepines could reduce 20-fold in 30 min of seizures. The objective of this study is to précis the existing proof that compares ‎the effect of valproate, phenytoin, diazepam, ‎‎phenobarbital, lacosamide, and levetiracetam on benzodiazepine-resistant convulsive status ‎‎epilepticus.‎

Method: This systematic review was conducted, including PubMed, Google Scholar, and EBSCO that examining randomized trials of non-benzodiazepine antiepileptic drugs in benzodiazepine-resistant ‎convulsive status epilepticus. Authors extracted the data, and then the author's names, year and region of publication, the study type, period of study, and the result were reported.  

Results: The review included 9 randomized studies that compared non-benzodiazepine antiepileptic drugs in terms of efficacy and adverse effects for SE management.      

Conclusion: Valproate, phenytoin, diazepam, ‎‎phenobarbital, lacosamide, and levetiracetam are all conventional agents that could be given as second-line management of status epilepticus and in cases of benzodiazepine-resistant convulsive status ‎‎epilepticus. Though, the use of these medications is restricted due to their toxicity.


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