TY  - JOUR
T1  - Effectiveness of Non-benzodiazepine Antiepileptic Drugs in Benzodiazepine-resistant ‎Convulsive Status Epilepticus
A1  - Anfal Atallah S Alamrani
A1  - Ali Mohamed S Alsada
A1  - Taif Naif R Alruwaili
A1  - Jumanah Faisal I Algoufi
A1  - Ammar Khalid S Alghanmi
A1  - Abdulmajeed Hisham A Alwabel
A1  - Abdulaziz Nasser A Alahmari
A1  - Abdullah Ayed A Alshahrani
A1  - Rahmah Mohammad M Alhawiti
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2021
VL  - 11
IS  - 1
DO  - 10.51847/nyFViZbJja
SP  - 149
EP  - 154
N2  - Time-dependent pharmacoresistance is a major therapeutic problem in SE and CSE. As seizures continue, pharmacoresistance develops progressively. The anti-seizure effectiveness of benzodiazepines could reduce 20-fold in 30 min of seizures. The objective of this study is to précis the existing proof that compares ‎the effect of valproate, phenytoin, diazepam, ‎‎phenobarbital, lacosamide, and levetiracetam on benzodiazepine-resistant convulsive status ‎‎epilepticus.‎ This systematic review was conducted, including PubMed, Google Scholar, and EBSCO that examining randomized trials of non-benzodiazepine antiepileptic drugs in benzodiazepine-resistant ‎convulsive status epilepticus. Authors extracted the data, and then the author's names, year and region of publication, the study type, period of study, and the result were reported.   

The review included 9 randomized studies that compared non-benzodiazepine antiepileptic drugs in terms of efficacy and adverse effects for SE management. Valproate, phenytoin, diazepam, ‎‎phenobarbital, lacosamide, and levetiracetam are all conventional agents that could be given as second-line management of status epilepticus and in cases of benzodiazepine-resistant convulsive status ‎‎epilepticus. Though, the use of these medications is restricted due to their toxicity.
UR  - https://eijppr.com/article/effectiveness-of-non-benzodiazepine-antiepileptic-drugs-in-benzodiazepine-resistant-convulsive-status-epilepticus
ER  -