International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2020   Volume 10   Issue 4

Development and Validation of Stability Indicating Rp-Hplc Method for the Estimation of Bisoprolol Fumarate in Bulk and Pharmaceutical Dosage Form
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Khagga Bhavyasri, J. Soujanya Goud, R. Sewthasri, Mogili Sumakanth
Citation
Bhavyasri K, Goud J S, Sewthasri R, Sumakanth M. Development and Validation of Stability Indicating Rp-Hplc Method for the Estimation of Bisoprolol Fumarate in Bulk and Pharmaceutical Dosage Form. Int j pharm phytopharm res 2020;10(4):49-70
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Abstract

A rapid and precise reverse phase High-Performance Liquid Chromatographic method has been developed for the validation of Bisoprolol fumarate, in its pure form as well as in tablet dosage form. Chromatography was carried out on a sunsil C18 (150mm X 4.6mm, 5µ)column using a mixture of Acetonitrile: Water (60:40)v/v as the mobile phase at a flow rate of 0.8ml/min, the spectrometric detection was carried out at 223nm. The retention time of the bisoprolol fumarate was 1.990min respectively. The method produces linear responses in the concentration range of 4-14µg/ml of bisoprolol fumarate. The method precision for the drug bisoprolol fumarate was found to be within the limits. The method is useful in the quality control of bulk and pharmaceutical formulations. 


International Journal of Pharmaceutical and Phytopharmacological Research
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