International Journal of Pharmaceutical and Phytopharmacological Research
ISSN (Print): 2250-1029
ISSN (Online): 2249-6084
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2020   Volume 10   Issue 3

A Review on Chiral Stationary Phases for Separation of Chiral Drugs ‎
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Celina Nazareth, Sanelly Pereira
Citation
Nazareth C & Pereira S. A Review on Chiral Stationary Phases for Separation of Chiral Drugs ‎. Int j pharm phytopharm res 2020;10(3):77-91
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Abstract

The resolution of chiral drugs is important in pharmaceutical analysis. The enantiomers of a chiral drug having identical physical and chemical properties in an achiral environment can be distinguished in a chiral environment provided that there are suitable interactions with a chiral selector. The enantiomers of a chiral drug can act differently with one enantiomer exhibiting pharmacological activity and the other exhibiting undesirable toxic effects. It is therefore critical to separate and analyze racemic drugs. The United States Food and Drug Administration guidelines, therefore, make it mandatory to market only the active enantiomer of chiral drugs. The availability of innovative chiral stationary phases makes the identification of enantiomers faster and effective. This review describes the different chiral stationary phases based on Pirkle type, protein, cyclodextrin, polysaccharide, ligand exchange, macrocyclic antibiotics and chiral crown ethers used in chiral chromatography. The various mechanisms involved in the chiral recognition of enantiomers are summarized. 


International Journal of Pharmaceutical and Phytopharmacological Research
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