Coronavirus disease 2019 (COVID-19) is an especially deadly respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It was first transmitted from animal to human in November 2019 in the open seafood market in Wuhan, and then from human to human, though the exact mode of transmission is not fully defined. This virus has spread throughout the world, and no effective vaccine or cure has been developed for it up to date. In this brief overview, we review a basic knowledge for COVID-19, its associated immune, pathology and histology, as well as available therapeutic approaches to provide clarification and future medically useful targets to grasp how COVID-19 co-circulates. The infection, prevention and supportive care for COVID-19 confirmed cases are the best-proven measures for the interventions until now; in addition, to use previous experience in the treatment of COVID-19 by various medicines for severe acute respiratory syndrome coronavirus (SARS-Cov), Middle East Respiratory Symptoms (MERS-CoV), Lupus, Anti-Malarial, Influenza Medicine, etc. were used to combat this disease. Nevertheless, various randomized trials of different drugs underway around the world can be used as a method for tracking the production of CVOID 19 vaccines, and interventions that continue worldwide. However, many vaccines are proposed by an international (privates and governmental bodies) trial against COVID-19. Therefore, the elimination of COVID-19 is an international priority, as the risk of disease will increase with increased death every day without viral spread control.