A complex modern study of the ratio effect of components of an ointment composition based on highly dispersed Zinc oxide modified with nanoscale silver on its physical and chemical properties is performed. It was found that at a concentration of glycerol equal to C = 10%, and at a concentration of methylcellulose C = 3%, the value of the active acidity of the ointment composition is optimal (pH = 6.5-7). Studies of the structural and mechanical properties of the ointment composition have shown that the wound-healing ointment composition is elastic and has thixotropy, which makes it possible to use it in the treatment of wound surfaces with complex relief.