Nigerian walnuts (Tetracarpidium conophoram) are used as a diet and medicine is on the increase to the extent that it is almost scarce in various regions where they are marketed. This study took a brief review on the nature, classification, properties, phytochemical components, nutritional values, and medicinal properties. There is rapid growth towards research and developments involving Nigerian walnut for drug development. From this study, it is discovered that Nigerian walnut has shown anti-oxidant, anti-inflammatory, anti-chelating nature, and high blood pressure control activities. Also, it has shown anti-lipidemic, anti-diabetes, anti-malarial, antimicrobial /antibacterial, and anticancer nature. The walnut has given reproductive assistance and aided sperm production and sperm quality, wound healing, anti-ulcer, and stomach disorders treatment features. The Nigerian walnut has energizing and weight management and diseases prevention capacity. It aids in bone health, skin or other tissues repairs, and could go a long way to assist in other health challenges. There has also encouraged usage in the aspect of complementary and alternative medicine. There seems to be a close relationship between walnut and bitter kola in nature, diet and medicinal properties Researchers and drugs producing companies should improve in their studies for more drug discoveries that could involve Nigerian walnut as it could assist in a Nobel discovery for treatment of difficult to treat diseases in the world.