A multifunctional material of 7.5 wt.% CuNPs decorated on CeO2 (7.5Cu-Ce) was synthesized by the green method using Cocoa pod extract as a reducing agent. The properties of the material were studied by various techniques including N2 physisorption (BET), X-ray diffraction (XRD), Raman spectroscopy (Raman), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HRTEM). In the next step, to investigate the applications of the material, it was screened for antibacterial activity against clinically important bacteria such as E. coli and Salmonella. The results showed high antibacterial activity, the minimum inhibitory concentrations (MIC) for E. coli and Salmonella are similar and reached 312.5 g.mL1. Also, the catalytic activities of the material were studied in the deep oxidation of CO or/and p-xylene. The conversion of CO was much easier than that of p-xylene. The CO conversion in the mixture is much lower than that of the pure substance. On the contrary, in the mixture of CO + p-xylene, the conversion of p-xylene is much higher compared to the pure p-xylene.