Dietary Inclusion of Aegle Marmelos Fruits in Wistar Rats

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Background: The favorer healthful plant Aegle marmelos is historically employed in India. There is no study on the effect of this plant on nephrotoxicity. Objectives: The goal of this study was to investigate the modulatory effects of dietary inclusion of Aegle marmelos against Cisplatin-induced nephrotoxicity in Wistar albino rats. Materials and Methods: Wistar albino rats of clusters I and II were fed basal diets whereas clusters III and IV were administered diets including 2% and 4% Aegle marmelos respectively for 7 days before Cisplatin administration. Cisplatin was administered to rats for 7 days leading to a diminution in the natural processes of the antioxidant activities in the rat. The kidney homogenates were investigated for superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH), and activity lipid peroxidation (LPO). The activity of SOD was determined by the Nitro blue tetrazolium (NBT) reduction process. Results: After administration of diets containing Aegle marmelos fruit, a substantial decline in the increased Lipid peroxidation and superoxide dismutase, Glutathione and Catalase concentration was noted. Conclusions: In conclusion, the nephroprotective activity of Aegle marmelos can be due to the inhibitory influence on these plant components as proved by increasing the activity of inhibitory enzymes and considerable modification in the physiological parameters.