Development of Directly Compressible Metformin Hydrochloride Using Size Reduction Technique

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Solid dosage forms have factually been related to conventional formulations such as tablets due to the ease of manufacturing, administration, and economic feasibility. Metformin hydrochloride shows poor compressibility during compaction, frequently resulting in soft and unacceptable tablets with a high tendency to cap. The present study was aimed to develop directly compressible metformin HCL by the ball milling technique. Powder of metformin was thoroughly examined using the angle of repose for flowability, laser diffraction particle size analyzer, scanning electron microscopy, differential scanning calorimetry, and Fourier transform infrared spectroscopy. Differential scanning calorimetry and Fourier transform infrared spectroscopy experiments displayed that the milled drug did not undergo any chemical or physical modifications. Tablets were compacted using a direct compression method, followed by evaluations of mechanical properties and disintegration testing. The results of milled metformin HCL showed a good compressibility profile and produced harder tablets compared to un-milled. It was concluded that milled metformin provides a good balance between tablet hardness and disintegration time.