The Effects of Vitamin D, Zinc, Calcium, and Magnesium Co-Supplementation on Glycemic Control, Lipid Profile, Liver Enzymes, blood pressure, and C–reactive protein in Type 2 Diabetic Patients

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Background: The purpose of this study was to evaluate the simultaneous supplementation of vitamin D, zinc, calcium, and magnesium on glycemic control, lipid profiles, liver enzymes, blood pressure, and C-Reactive Protein (CRP) in patients with type 2 diabetes. We assumed that vitamin D, zinc, calcium, and magnesium co-supplementation might improve glycemic control and insulin release.

Methods: The present study was a double-blind, randomized clinical trial conducted on two groups: Intervention group (n = 32) (200 mg vitamin D, 4 mg zinc, 400 mg calcium, and 100 mg magnesium twice daily for eight weeks), and Control group (n = 32) (placebo twice daily for eight weeks). At the beginning and end of the study, the following measurements were evaluated: 3-day 24-hour food recall, blood pressure, anthropometric variables, physical activity, and biochemical tests.

Results: After eight weeks, the intervention group showed a significant decrease in fasting blood glucose (P = 0.001), increase in QUICKI (P = 0.013), decrease in serum cholesterol (P = 0.001), and decrease in GGT enzyme (P = 0.001) compared to the control group.

Conclusion: Concurrent supplementation of vitamin D, zinc, calcium, and magnesium had beneficial effects on the fasting blood sugar, QUICKI, serum cholesterol, and serum GGT in diabetic patients.