Background: Rheumatoid arthritis (RA) is emerging as a prevalent disorder with a higher rate of complications, morbidity, and mortality. This highlights the need for Ayurvedic medicines for reducing the impact of RA. Aims and Objective: To study the effect of 3-month treatment of Guduchi Ghan Vati (Aqueous extract of Tinospora cordifolia) and Sunthi churna (Zingiber officinale powder) along with Virecana Karma (medicated purgation) in patients with RA. Material and Methods: 40 patients of age group 20-60 years, of either sex meeting the European League Against Rheumatism (EULAR) criteria of RA were randomly divided into two groups, Control and Intervention. The intervention group received Virecana (medicated purgation) followed by Guduchi Ghan Vati (Aqueous extract of Tinospora cordifolia) 4 tab TDS (1 tab= 500 mg), Sunthi churna (Zingiber officinale powder) 5g BD, while the control group was given Tab. Etoricoxib at a fixed dose of 90 mg OD for 90 days. All participants gave written informed consent. An assessment was done by improvement in chief complaints and biochemical parameters (RA-titre, CRP, Anti-CCP titers and TNF-alpha) at baseline and at the end of 12 weeks. Adverse events and drug tolerability were analyzed. Results: Clinical symptoms and biochemical parameters were significantly reduced from beginning to end of the treatment (P<0.001). Conclusions: The study provided good evidence in support of the efficacy and safety of Virecana Karma (medicated purgation) followed by Guduchi Ghan Vati (Aqueous extract of Tinospora cordifolia) and Sunthi churna (Zingiber officinale powder) in the management of Rheumatoid arthritis.