%0 Journal Article
%T Sexually Dimorphic Effect of Zonisamide on Behavioral ‎Locomotor Activity in a Rat Model of Parkinson's disease
%A Ardeshir Moayeri
%A Zynab Khalili
%A Marzieh Darvishi
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2019
%V 9
%N 5
%P 27-36
%X Introduction: Zonisamide (ZA) is a new drug that has been shown to be effective ‎against motor damage in Parkinson&#39;s disease. However, the behavioral effect of ZA ‎has not been described in male and female of rats. The aim of this study was to ‎evaluate sexually dimorphic effects of ZA on behavioral locomotor activity in a rat ‎model of Parkinson&#39;s disease. Materials & Method: 48 adult Wistar rats (24 male ‎and 24 female) were randomly divided into eight groups, consisting of four groups ‎of each sex: 1) sham group 2) PD group (Parkinson&#39;s model) 3) ZA group ‎‎(vehicle) and 4) PD plus ZA group (Parkinson&#39;s model with ZA treatment). ‎Parkinson&#39;s disease was administered by an injection of 6-hydroxydopamine (6-‎HD) into medial forebrain bundles. The drug was orally administered at a dose of ‎‎50 mg / kg every 24 hours for 7 days after surgery. The behavioral effects of ‎apomorphine-induced rotation and spontaneous motor tests (elevated body swing, ‎cylinder, and footfault test) were investigated in rats of both sexes. Results: ZA ‎decreased contralateral rotations in male and female rats compared to the negative ‎control group (p < 0.05) that is correlated with cell loss. ZA improves spontaneous ‎motor tests in both sexes, and this finding is statistically significant. In the PD plus ‎ZA group, the male and female comparisons demonstrated that step through ‎latency in female was higher than that of the male (p  
%U https://eijppr.com/article/sexually-dimorphic-effect-of-zonisamide-on-behavioral-locomotor-activity-in-a-rat-model-of-parkinsons-disease