Protective Effect of Terminalia Chebula Fruit Extract on Ethanol-Induced Hepatotoxicity in Albino Rat

Vuyyala Balakrishna , Takhalapally Lakshmi , Deepak Pawar , Chedurupally Lavanya

Abstract

The purpose of this study was to guage the impact of Terminalia chebula fruit extract on liver inhibitor enzymes in ethanol-induced hepatotoxicity in rats. Rats were divided into six completely different teams every having six. Group one served as a control, cluster two received fourty percentof ethyl alcohol (2 ml/100 g, oral), in sterile water, Groups 3, 4 and 5 served as extract treatment teams and received 50,100 and 200 mg/kg, orally, ethanolic fruit extract of T. chebula (TCE) and cluster three served as standard cluster and received silymarin twenty five mg/kg orally. All the treatment protocols followed twenty one days, and when those rats were sacrificed, the liver was taken for inhibitor and microscopic anatomy studies, severally. The ethanol-treated cluster rats (G2) showed variable decrease in inhibitor parameter (catalase, glutathione, and glutathione reductase) levels. In the present study treatment with T.Chebula fruit extract significantly decreased the elevated levels of SGOT, SGPT, ALP, Total bilirubin and increased the levels of Total proteins. Administration of ethanolic trichloroethane considerably prevented ethanol-induced elevation within the levels of malondialdehydelipide peroxidation and attenuated inhibitor parameters in experimental teams of rats. The impact of extract was compared with a standard drug, silymarin. The changes in antioxidant parameters were supported by histological profile. It is concluded that the ethanolic fruit TCE protects against ethanol-induced oxidative liver injury in rats.



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