TY  - JOUR
T1  - In-Silico Evaluations of Some α -Methylene-γ-Butyrolactone Analogues
A1  - Feten Beji
A1  - Reem al Harbi
A1  - Arshi Naqvi
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2020
VL  - 10
IS  - 4
SP  - 138
EP  - 145
N2  - The efficacy along with proper pharmacokinetics and toxicity profiling is the major determinants for the present scenario of successful drug development. The toxicity prospect accompanying weak ADMET (absorption, distribution, metabolism, elimination, and toxicity) profile are the vital justifications of late costly jeopardy of drug development. To predict the ADMET idiosyncrasy, in-silico inspection of some α-methylene-γ-butyrolactones (2-7) was induced on the foundation of several physico-chemical criteria to predict their pharmacokinetic, pharmacodynamic, drug-likeness, bioactivity and molecular docking profile exploiting several computational tactics. 
UR  - https://eijppr.com/article/predictive-evaluations-of-some-methylene-butyrolactone-analogues-via-in-silico-pharmacokinetic-pharmacodynamic-bioactivity-and-molecular-docking-approaches
ER  -