%0 Journal Article
%T In Vitro Biological Activity of Ethanolic Extract of Maramiyah (Salvia Libanotica) and Its Combination with Essential Oil
%A Samreen Soomro
%A Sibgatullah Sangi
%A Akbar Ali Mashooq
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2019
%V 9
%N 2
%P 32-37
%X Introduction: Salvia libanotica (sage) is one of most famous and traditional herbs popular throughout the Arab world. Extracts of S. libanotica are found to be useful as traditional medicine. The current study aimed to further explore the phyto-constituents of the plant and its biological activity. Methodology The present study investigated the phytochemical constituent of sage and its synergism with essential oils using classical method. Biological activity was evaluated as immunomodulatory activity, anti-bacterial, cytotoxic and anti-cancer activity in vitro. Results: One hundred gram of ethanolic crude extract was prepared from sage leaves using classical method; its combination with essential oil was prepared as 1:1 ratio. Phytochemical studies demonstrated positive results for tannins, flavonoids and triterpenes/sterols. Immunomodulatory activity revealed that ethanolic extract is effectively inhibiting the free radicals generated during inflammation. Mild antibacterial activity was found against all gram negative bacteria in ethanolic extract but not with essential oils. Whereas, gram positive bacteria Staphylococcus aureus and Bacillus subtilis were significantly (p
%U https://eijppr.com/article/in-vitro-biological-activity-of-ethanolic-extract-of-maramiyah-salvia-libanotica-and-its-combination-with-essential-oil