Medicinal herbs are plants that have medicinal properties for various diseases and also maintain human and animal health, As a result of the concerns about the side effects of conventional medicine, the use of natural products as an alternative to conventional treatment in the healing and treatment of several diseases has been increased in the last decades. This study aimed to evaluate the effect of different levels of Ginger and Mentha on the immune changes in rats injected with carbon tetrachloride (CCl4). The experiment was performed in the animal house. The rats were fed on a basal diet before starting the experiment for 1 week, then divided into 2 main groups, the first group (n= 4) was fed on the basal diet only as a control negative normal rats for 28days. The rats of the second main group (n= 32) were injected with CCl4. The second main group was divided into eight sub-groups, including three groups fed with different concentrations (5%, 10%, and 15%) of Mentha and three groups fed with different concentrations (5%, 10%, and 15%) of Ginger and one group mixed of all plants and one control positive group infected with the disease and did not feed on the experimental diet. The results demonstrated that group 8 (rats fed on a diet containing 15% Mentha) showed the lowest level in lymphocytes among all treatment groups and recorded the best results compared to the normal group. Moreover, the result showed that there was no significant difference among groups 3, 4, and control positive groups. Groups 5, 7, and 9 showed similar (P>0.05) mean values of hematocrit. Finally, group 6 (rats fed on a diet contain 5% Mentha) and group 8 (rats fed on a diet containing 15% Mentha) showed the lowest levels of hematocrit among all treatments and recorded the best results compared to the normal group.