TY - JOUR T1 - Failure Rate and Associated Factors with Use of Mini-Screws in Orthodontic Treatments: A Systematic Review and Meta-analysis ‎ A1 - Ahmad Sheibaninia JF - International Journal of Pharmaceutical And Phytopharmacological Research JO - Int J Pharm Phytopharmacol Res SN - 2250-1029 Y1 - 2020 VL - 10 IS - 4 SP - 22 EP - 27 N2 - Aim and Background: This meta-analysis aimed to study the failure rate and related risk factors associated with the use of orthodontic mini-screws in anchorage reinforcement. Method and Materials: This meta-analysis was started with a search for keywords ‘mini-screw’, ‘micro-screw’, ‘mini-implant’ and ‘failure rate’ in the databases of several search engines, including Google Scholar, PubMed, Science Direct and Scopus. Articles were selected based on inclusion criteria (e.g. clinical trials, retrospective, and human studies) and exclusion criteria (e.g. on-plant, palatal and conventional implants). The quality of selected studies for this study was assessed by the PRISMA checklist. The mean and standard deviation of failure rates were determined. The random-effect model was used to evaluate the effect of each risk factor on the failure rate. This study aimed to calculate the failure rate, and identify the risk factors involved in the failure rate of using mini-screws by meta-analysis. Results: A total of 20 out of 1,995 studies were selected up to 2016, to assess the overall failure rate of mini-screw, and to investigate the associated risk factors. Of 4,826 mini-screw implants used in 2,327 patients, the overall failure rate was 15.08% (95% CI). The statistical significance was set at P UR - https://eijppr.com/article/failure-rate-and-associated-factors-with-use-of-mini-screws-in-orthodontic-treatments-a-systematic-review-and-meta-analysis ER -