Evaluation of Vitamin D Levels in Patients with Hepatitis B Virus

Seyed Hamid Moosavy , Abdolazim Nejatizadeh and et al


Introduction: Vitamin D deficiency is likely a substantial contributor to the progression of the hepatitis B virus ‎‎(HBV) to chronic hepatitis B (CHB), cirrhosis (LC) and hepatocellular carcinoma (HCC). This study ‎aims to compare serum vitamin D levels between patients with HBV and healthy controls.‎ Method: In this cross-sectional study in southern Iran, 114 HBV patients including 59 active chronic ‎hepatitis, 42 inactive carriers, 15 patients with liver cirrhosis and 104 healthy controls were ‎enrolled. Demographic data and respective biochemical assays were carried out. T-test, Mann-‎Whitney, and regression using SPSS16 software were performed to determine the effect of vitamin ‎D on other variables.‎ Results: Serum vitamin D levels lower than 30 ng / ml was observed in 94 cases (81.03%) in HBV group and ‎in 70 cases (67.30%) in controls. The prevalence of severe deficiency (<10 ng / ml) and between ‎‎10-20 ng / ml in HBV patients was 51.7%. The frequency in the subgroups of HBV was as follows: ‎CHB (% 43.10), L.C (% 80), Inactive carriers (% 52.41), while in control group (H.C) was (44.20%) ‎‎(P <0.001). Distribution of vitamin D deficiency in rural people was more than urban population ‎‎(OR = 2.321), which is statistically significant in two groups (P=0.004). Logistic regression analysis ‎for ALT (P = 0.38), AST (P = 0.005), AFP (P = 0.005), and ALB (P = 0.085) showed a meaningful ‎associations.‎ Conclusion: Our study showed that vitamin D levels was significantly lower in all groups of patients with HBV ‎compared with healthy controls. Of note, in healthy controls, insufficient levels of vitamin D ‎compared to the standard range was observed. Therefore, conducting large population-based ‎screening and underlying studies to identify the respective causes.

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