Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective and ‎Nephroprotective Activity in Rats

Srikanta Chandra , Avik Das , Tathagata Roy , Preeta Bose , Lucky Mukherjee , Jyotirmay ‎Samanta , and et all

Abstract

Objective: This investigation was conducted to study the hepatoprotective and nephroprotective activities of methanolic extract of Clitoria ternatea in Cisplatin and CCl4 induced in rats. Methods: The methanolic extract of the aerial part of Clitoria ternatea plant was investigated for its nephroprotective and hepatoprotective activities in animal experimental models. Nephrotoxicity was induced by 16 mg/kg BW of Cystone. The standard drug was Silymarin and the test drug was 0.5 and 1 g/kg BW of the methanolic extract of Clitoria ternatea. Hepatoxicity was induced by CCl4. The standard drug was 100 mg/kg BW of cisplatin and the test drug was 0.5 and 1 g/kg BW of Clitoria ternatea extract. Results: In the hepatoprotective activity, the positive control group was provided by CCl4 and increased levels of SGPT, SGOT, and ALP were observed compared to the negative control group, whereas Test (2) group was provided by 1000 mg/kg of the methanolic extract of Clitoria ternatea, that led to decreased levels of SGPT, SGOT, and ALP compared to the standard group. In the nephroprotective activity, the positive control group was provided by CCl4 and increased levels of urea and creatinine were observed, whereas Test(2) group was provided by 1000 mg/kg of the methanolic extract of Clitoria ternatea, leading to decreased levels of urea and creatinine. Conclusion: On evaluating biochemical parameters it was found that 1000 mg/kg BW of the methanolic extract of Clitoria ternatea showed hepatoprotective and nephroprotective activities in rats‎‎.



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