The aim of the current study was to evaluate the antidiarrhoeal activity of the 70% hydroalcoholic extract of Moringa oleifera pods using different animal models of diarrhea in rats. Castor oil and magnesium sulfate-induced diarrhea rats were studied using loperamide as reference standard drug in rats. The onset of diarrhea, the mean number of fecal drops and mean weight of feces were determined. Prostaglandin E2 and castor oil-induced enterpooling was studied in rats by measuring the mean volume of intestinal fluid. Charcoal meal test was performed using atropine sulfate as a reference standard in rats. The mean distance passed by charcoal meal and mean percent movement of charcoal after 30 min were recorded. The results of the present study revealed that the extract of Moringa oleifera pods demonstrated dose-dependent antidiarrhoeal activity in all experimental animal models of diarrhea due to the presence of pharmacologically effective component(s).