%0 Journal Article
%T Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats
%A Zahra Sadat Hussaini
%A Hakima Askndari
%A Kawsar Alami
%A Sayed Yousof Mousavi
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2021
%V 11
%N 1
%R 10.51847/EZXsU4H
%P 63-69
%X The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7th, 14th, and 21st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7th, 14th, and 21st days (P
%U https://eijppr.com/article/effect-of-rheum-ribes-and-urtica-dioica-on-type-2-diabetic-rats