%0 Journal Article
%T Development and Validation of Stability Indicating Rp-Hplc Method for the Estimation of Bisoprolol Fumarate in Bulk and Pharmaceutical Dosage Form
%A Khagga Bhavyasri
%A J. Soujanya Goud
%A R. Sewthasri
%A Mogili Sumakanth
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2020
%V 10
%N 4
%P 49-70
%X A rapid and precise reverse phase High-Performance Liquid Chromatographic method has been developed for the validation of Bisoprolol fumarate, in its pure form as well as in tablet dosage form. Chromatography was carried out on a sunsil C18 (150mm X 4.6mm, 5µ)column using a mixture of Acetonitrile: Water (60:40)v/v as the mobile phase at a flow rate of 0.8ml/min, the spectrometric detection was carried out at 223nm. The retention time of the bisoprolol fumarate was 1.990min respectively. The method produces linear responses in the concentration range of 4-14µg/ml of bisoprolol fumarate. The method precision for the drug bisoprolol fumarate was found to be within the limits. The method is useful in the quality control of bulk and pharmaceutical formulations. 
%U https://eijppr.com/article/development-and-validation-of-stability-indicating-rp-hplc-method-for-the-estimation-of-bisoprolol-fumarate-in-bulk-and-pharmaceutical-dosage-form