TY - JOUR T1 - Antidiabetics and Glucose Uptake Activity of Prosopis Farcta on STZ-Induced Diabetic Rats and 3T3 L1 Adipocyte Cell Line A1 - Fatemeh Nosrati A1 - Mahboobeh Gholami A1 - Abolfazl Mohammadi A1 - Najmeh Nazari A1 - Hamidreza Hemati A1 - Farshad Zamani A1 - Hossein Nazari A1 - Hadi Amrollahi JF - International Journal of Pharmaceutical And Phytopharmacological Research JO - Int J Pharm Phytopharmacol Res SN - 2250-1029 Y1 - 2020 VL - 10 IS - 5 SP - 22 EP - 29 N2 - Introduction and Objectives: Today researchers are trying to find the anti-diabetic effects of dietary and medicinal plants as alternative medicines and chemicals, which have been traditionally used for centuries. The purpose of this study was to investigate the hypoglycemic effects of the extract of Prosopis farcta on adult male rats and glucose uptake activity in 3T3 L1 adipocyte cells. Results: Groups treated with the doses of 40 mg/kg BW of the extract lowered the blood glucose levels similar to glibenclamide. A significant decrease in plasma glucose levels was shown in the rats treated with 60 mg/kg BW of the extract compared with the group treated with glibenclamide. The results of this study indicate that the glucose-lowering property of the Prosopis farcta extract is more effective than glibenclamide. The maximum blood plasma glucose level lowering was shown after 2 days of treatment with the extract of P. farcta at 60 mg/kg BW oral and 8 ml/kg BW subcutaneous administrations compared to the control group (p UR - https://eijppr.com/article/antidiabetics-and-glucose-uptake-activity-of-prosopis-farcta-on-stz-induced-diabetic-rats-and-3t3-l1-adipocyte-cell-line ER -