Objectives: Hand osteoarthritis is one of the most common diseases in older adults, with negative consequences in the daily life. This study was aimed to investigate the effect of Kinesio Taping on the hand functions and symptoms in patients with hand osteoarthritis. Methods: A total of 9 subjects, in the age range of 64 to 75, participated in a quasi-experimental study. All the patients were assessed three times using Numeric pain rating scale, Pinch gauge, Dynamometer, and Goniometer. Wilcoxon’s signed rank test was also used for the statistical analysis. Results: Analysis of data at post intervention assessment revealed a significant improvement in pain, grip, and pinch strength, as well as the range of motion. In addition, the follow up analysis showed a significant change, as compared to the initial analysis. Discussion: It seems that Kinesio Taping has a positive effect on improving the hand functions and symptoms in patients with hand osteoarthritis. Given the lack of information in this area, further research is needed.