Introduction: Acute renal failure is one of the major problems of patients admitted to the ICU, for which several treatments have been suggested, such as adequate hydration and administration of diuretics. This study aimed to evaluate the effect of adding albumin to mannitol-Lasix composition in adolescent ICU patients with acute renal failure. Methods: This study is a double-blind clinical trial that was performed on 100 adolescent patients in the ICU of Bahonar Hospital in Kerman, Iran from March 2013 to March 2015. Patients with acute renal failure. Patients were randomly divided into two groups. In group A, the combination of mannitol-Lasix-albumin and group B, only mannitol-Lasix was administered as an infusion for up to 48 hours. Variables such as Central venous pressure (CVP), Peripheral edema, PaO2/Fio2, Urine volume, Nitrogen Urea Blood (BUN), creatinine (Cr) before and at the end of the infusion were evaluated and compared. Results: Before the intervention, the demographic findings and the variables were the same in both groups. But after 48 hours in group A with a significant increase in urinary goiter, the rate of edema and CVP compared to group B was reduced and oxygenation of patients was increased, while the amount of BUN and creatinine in the two groups was not significantly different. Conclusion: It seems that the addition of albumin to the mannitol-lazyx combination in adolescents with acute renal failure increases diuresis and oxygenation and reduces peripheral edema, but has little effect on renal function.