TY  - JOUR
T1  - Systems Pharmacology of Plant-Derived Anti-Inflammatory Agents: Multi-Target Modulation, Pathway Crosstalk, and Translational Evidence Mapping
A1  - Ahmed Youssef
A1  - Khaled Hassan
A1  - Mahmoud Elamin
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2025
VL  - 15
IS  - 6
DO  - 10.51847/btEhGfEzej
SP  - 47
EP  - 58
N2  - Plant-derived anti-inflammatory agents occupy an important position in natural product pharmacology because many compounds, extracts, and phytochemical classes interact with inflammatory mediators through distributed biological mechanisms rather than through a single isolated target. This article develops an original systems pharmacology framework for interpreting plant-derived anti-inflammatory evidence across agent identity, chemical characterization, target mapping, multi-target modulation, pathway crosstalk, oxidative stress interfaces, immune-metabolic context, safety evidence, and translational evidence boundaries. The framework is designed to distinguish plant-derived compounds, botanical extracts, and phytochemical classes from predicted targets, experimentally supported targets, inflammatory mediators, immune-cell contexts, pathway modulation, and clinical evidence. It emphasizes that multi-target modulation can support mechanistic hypothesis generation when target confidence, biological context, exposure plausibility, and validation needs are explicit. It also positions pathway crosstalk as a systems-level interpretive layer that requires causal caution because signaling changes do not automatically establish therapeutic benefit. Translational evidence mapping is proposed as a structured method for aligning in silico, in vitro, mechanistic, preclinical, safety, exposure, and human evidence with appropriate claim boundaries. The main contribution is a cautious, evidence-aware framework for organizing plant-derived anti-inflammatory research without presenting systems pharmacology, network inference, or biomarker modulation as clinical proof.
UR  - https://eijppr.com/article/systems-pharmacology-of-plant-derived-anti-inflammatory-agents-multi-target-modulation-pathway-cro-pykvuvz7bfb61oe
ER  -