Objective: Angiography is recognized as the golden standard for studying coronary artery diseases and its use is increasing widely. However, the most common method for screening patients suspected of coronary heart disease prior to invasive interventions is using the angiography test. The aim of this study was to determine the incidence of significant LAD involvement in angiography of the coronary arteries in patients with ischemia in blood supplied regions. Methods: During this cross-sectional study, patients referred to the emergency unit of Imam Ali and Imam Reza hospitals in Kermanshah, as well as Farshchian hospital in Hamadan were studied. After obtaining the history and initial examination, noninvasive angiography was conducted on patients. Eventually, the results of angiography were analyzed. Data were analyzed using SPSS software. Results: 87 (64.4%) out of 135 patients, were males, and 48 (35.6%) were females. The age of the patients was recorded to be between 47-77 years with a mean and standard deviation of 61.65 ± 8.66 years. Angiographic results showed that, 75% of the patients had LAD involvement, which means that 34 patients were involved with LAD. Conclusion: According to the results of this study, using coronary artery angiography is beneficial in patients with cardiac pain and can evaluate the cardiac pain with a high sensitivity, specificity and accuracy.