Mother milk feeding is associated with decreased risk of necrotizing enterocolitis and improves neurodevelopment among low-birth-weight infants. This is a systematic review was carried out, including PubMed, Google Scholar, and EBSCO that examining randomized controlled trials, observational, and experimental studies that study the role of human milk in the management of necrotizing enterocolitis. The study included 6 studies and concluded that; while the etiology of necrotizing enterocolitis is not well understood, studies have reported that human milk feedings reduce its’ incidence significantly. Larger scale experimental studies more publications studies are needed to provide guidelines for physicians to use this approach in these cases. Also, further studies on study pasteurized donor milk role in the management of this case.