%0 Journal Article
%T ‎ Repair Effects of Depakene on Neuropathological Changes in Cuprizone Model of Demyelination
%A Somayeh Sohaili
%A Ardeshir Moayeri
%A Marzieh Darvishi
%A Naser Abbasi
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2020
%V 10
%N 5
%P 256-269
%X Introduction: Epigenetic advances have led to the production of a specific class of medicines called epigenetic drugs, medications that inhibit histone deacetylase (HDACi). Valproic acid (VPA), known as HDACi, has neuroprotective effects. The current study investigated the histological and functional changes of a demyelination model associated with VPA treatment in C57BL/6 mice. Material & method: In the present study, 48 C57BL/6 mice were classified randomly into eight groups: sham, cuprizone (0.2%), three VPA groups (treated with 100, 200, and 300 mg/kg of VPA), three groups of cuprizone plus VPA (100, 200, and 300 mg/kg of VPA). One week after treatment, gliosis, apoptosis, and remyelination were examined histologically, and locomotor function was assessed by the behavioral test. Result: The expression of GFAP and caspase-3 in the untreated controls had the highest immunofluorescence, while it was significantly decreased in the VPA groups (P
%U https://eijppr.com/article/repair-effects-of-depakene-on-neuropathological-changes-in-cuprizone-model-of-demyelination