Objective: This study is aimed at determining the relationship between the results of angiography and echocardiographic stress test in patients with coronary pain. Methods: In this cross-sectional study, patients referred to the emergency unit of Imam Ali, Imam Reza, and Farshchian hospitals in Hamedan with coronary pain complain were evaluated. After obtaining a history and an initial examination, echocardiography stress test was conducted on patients. After that, non-invasive angiography was done on patients. Eventually, the results from the echocardiography stress and angiography tests were compared and analyzed using SPSS software. Results: Results indicate that 75% of angiography and 70% of echocardiography stress patients were diagnosed with LAD. Values for sensitivity, specificity, positive and negative predictive value, and accuracy of echocardiography stress test in diagnosing LAD were 93.1%, 100%, 100%, 82.9%, and 94.8% respectively. Angiography showed that 50% of the patients suffer from RCA and it was 55 for echocardiography. Sensitivity, specificity, positive and negative predictive value, and accuracy of echocardiography test in diagnosing RCA were 100%, 89.7%, 90.5%, 100%, and 94.8%, respectively. Angiography showed that 34% of patients suffer from LCX involvement. This percent was 50 for echocardiography stress test. Sensitivity, specificity, positive and negative predictive value, and accuracy of the echocardiographic stress test in diagnosing LCX involvement in patients were 100%, 76.4%, 68.6%, 100% and 84.4% respectively. Conclusion: Based on results, using echocardiography stress test in patients with coronary pain is beneficial. This method can evaluate the coronary pain with a high sensitivity, specificity, and precision.