Recent Developments in Chiral Stationary Phases: A Mini-Review

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The purification of racemic drugs into enantiopure drugs is an extreme demand of the pharmaceutical industry. In racemic drugs, two or more enantiomers are often present. In these isomers, one isomer may be pharmacologically active whereas another isomer(s) may be inactive or in teratogenic (toxic) form. The resolution of pharmacologically active isomer from inactive or teratogenic isomer is an extreme need. As a result, the development of resolution techniques to obtain the enantiopure drug is very essential to treat the disease. In the present review, recent developments of different chiral stationary phases (CSPs) such as pirkle, polysaccharides and polypeptides, inclusion, ligand-exchange, macrocyclic antibiotics, and miscellaneous CSPs in a resolution of racemic drugs/mixtures are discussed. The progress of these CSPs in high performance liquid chromatography (HPLC), gas chromatography (GC), capillary electrophoresis (CE), supercritical fluid chromatography (SFC), and simulated moving bed (SMB) chromatography is discussed. Different interactions between CSPs and analytes which attributes for resolution of racemic drugs are also discussed.