The main intention of floating microspheres is to elevate gastro-retentive time, there by drug release and bioavailability. Floating drug delivery systems glide on gastric fluid for an extended time without leaving the stomach and give good accessibility of the drug systemically and good duration of action for the prolonged period of time. Gastro-retentive microspheres are preferred for local action, local absorption, and preventing drug deterioration at the stomach. This article was made by pearly referring to published research papers of both online and offline journals on gastro retentive microspheres made by factorial design. The authors succeeded in collecting the information about the past decade of work done on gastro retentive drug delivery systems using factorial design. The authors from this study conclude that factorial design is an appreciable technique in the optimization of the gastro retentive dosage form in the form off microspheres for the drug delivery for the extended period of time.