TY - JOUR T1 - Optimization of Lamivudine Solid Dispersions by Central Composite Design A1 - Hindustan Abdul Ahad A1 - Haranath Chinthaginjala A1 - Samhitha Rao Bitraganti A1 - Rahul Raghava Dasari A1 - Gamaa Birir Mohamed Musa A1 - Varam Naga Jyothi JF - International Journal of Pharmaceutical And Phytopharmacological Research JO - Int J Pharm Phytopharmacol Res SN - 2250-1029 Y1 - 2021 VL - 11 IS - 4 DO - 10.51847/1KVQAZGWqU SP - 18 EP - 23 N2 - Lamivudine (LVD) is in BCS class II with the issue of minimal oral bioavailability. This issue can be improvised by complexing LVD with polyethylene glycol-4000 (PEG-4000) and Pluronic F-68 (PF-68) by formulation design. The attempt optimized LVD tablets through central composite design (CCD). LVD tablets will be with > 95% dissolution after 30 minitues by employing PEG-4000 and PF-68. Nine LVD tablets were formulated by design and assessed for physicochemical constraints, disintegration time, and drug dissolution. The separate and mutual consequences of PEG-4000 and PF-68 on the disintegration time of LVD tablets are highly significant (P< 0.01). Intermittent levels of PEG-4000 and more levels of PF-68 gave less time for disintegration and a greater amount of drug dissolved at the end of 30 minitues. The study concludes that PF-68 decreases the disintegration time with its concentration and PEG-4000 concentration ingresses the drug release from the formulation. The study also discovered that the optimized LVD tablet with > 97.5% dissolution in 30 minitues could be formulated by employing PEG-4000 at 30 mg and PF-68 at 44.8 mg (F-7). UR - https://eijppr.com/article/optimization-of-lamivudine-solid-dispersions-by-central-composite-design-upbt2jurhnzlmwu ER -