Novel Multi-Herbal Formulation (SS-IM-21) and its Sanative Effect in CCl₄ Induced Experimental Animals

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The nutritional status can be determined by serum proteins. Normal protein levels being off-balance signals possible life-threatening organ malfunction. The study's primary goal was to ascertain the serum and tissue protein levels in response to CCl₄ intoxication and their reduction by a newly created innovative herbal medicine (SS-IM-21). Swiss albino adult healthy mice were divided into four groups of six each based on weight. Group I served as the control, Group II was given Multi herbal formulation (SS-IM-21) 400 mg/kg/day, Group III was given carbon tetrachloride (CCl₄) 1 ml/kg-bw, and Group IV was given CCl₄ combined with SS-IM-21 (400 mg/kg). In contrast to untreated animals, therapy with Multi herbal formulation (SS-IM-21) normalized body weight, food intake, and water intake in mice after administration of carbon tetrachloride (CCl₄). When compared to the control, Group III receiving CCl₄ treatment saw lower serum levels of total protein, albumin, and globulin. In comparison to CCl₄-impaired animals, pre-treatment with SS-IM-21 significantly (p<0.001) raised the levels of total protein, albumin, and globulin in serum, liver, and kidney. However, a greater albumin/globulin ratio makes it evident that the liver and kidney may be negatively impacted by CCl₄ medication.  By preserving the albumin/globulin ratio, the multi-herbal formulation (SS-IM-21) safeguards the kidney and liver. In conclusion, it is possible to predict that antioxidant-enhanced new formulation with phytochemicals preserve normal protein patterns and shield the organism from a variety of dysfunctions.