Nanotechnology is a branch of science which has engineered and manufactured materials at the atomic, molecular, and supramolecular scale. Nanotechnology refers to structures at roughly the nano-metric scale (10-9 m) in at least one dimension. Here, we focus on the application of nanotechnology to drug delivery, with emphasis on Liposomes. Several applications could enable entirely novel classes of therapeutics. The production of various systems of liposomes at nano scale and the integration of the resulting nanostructures into larger systems is interesting. In this regard, the effect of nanotechnology in early diagnosis and targeted drug therapy of diseases such as cancers, diabetes, infections, etc. is indubitable. Indeed, the small size, customized surface, improved solubility, and multi-functionality of nanostructures can lead to better bio-compatibility, bio-accessibility, and efficacy under different conditions.