TY  - JOUR
T1  - Multiscale Pharmacology of Natural Products: Linking Molecular Features, Cellular Pathways, Organ-Level Effects, and Clinical Relevance
A1  - Laura Keller
A1  - Thomas Lehmann
A1  - Simon Brunner
A1  - Christoph Meier
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2026
VL  - 16
IS  - 3
DO  - 10.51847/lLzl3RxJ8r
SP  - 38
EP  - 51
N2  - Natural product pharmacology routinely spans multiple biological and interpretive scales, from phytochemical identity and molecular interactions to cellular pathway modulation, tissue responses, organ-level effects, and clinical relevance. This scale diversity creates a recurrent translational problem because evidence generated at one level is often interpreted as if it were sufficient to justify conclusions at another. The purpose of this article is to propose a multiscale pharmacology framework for natural product research that preserves scale-specific evidence while organizing structured links across molecular, cellular, organ-level, exposure, safety, and translational domains. The framework begins with natural product identity, botanical source, phytochemical composition, and molecular feature characterization, then progresses through bioactivity evidence, target annotation, target engagement hypotheses, off-target risk, and cellular pathway mapping supported by omics evidence where available. It next incorporates tissue context, organ-system relevance, pharmacokinetic exposure, ADME considerations, and safety signals so that organ-level interpretation is not detached from exposure-response reasoning. Clinical relevance is addressed through biomarker interpretation, disease-phenotype mapping, clinical endpoint boundaries, and uncertainty-aware translational mapping. Validation is treated as a central boundary condition rather than a downstream formality, with explicit attention to scale-transition gaps, evidence triangulation, expert review, and feedback updating. The main contribution is an original conceptual framework that supports research prioritization and mechanism-oriented interpretation while avoiding unsupported clinical or therapeutic claims.
UR  - https://eijppr.com/article/multiscale-pharmacology-of-natural-products-linking-molecular-features-cellular-pathways-organ-le-jlipipiichxtr3r
ER  -