The messenger ribonucleic acid (mRNA) vaccine has proven to be beneficial in containing the severe acute respiratory syndrome coronavirus. However, some school thought that it is not as effective as proposed, even though many others attest to its efficacy. The study employed scoping review on online journal and book publications to reveal the pharmacokinetics and pharmacodynamics of the mRNA vaccine. In this work, we have discussed the mechanism of action of the self-amplified messenger ribonucleic acid vaccines, the determinants of the clinical efficacy, and the possible reasons behind the varying efficacies that different populations may experience. We provided possible ways to tackle this challenge. In providing these solutions, we discussed pharmacogenetics viz-a-viz epigenetics. The study also used figures to elaborate on the factors that determine the clinical efficacy of mRNA vaccines. We are confident that caregivers and public health officials in the tropics would find the information interesting and invaluable.